Research Fields

Our university institution has obtained the support of the ministry of Health, Labor and Welfare for scientific research. We briefly present our latest projects.

1) In vivo cell observation with ultra-magnifying endoscope

(Inoue Haruhiro , Ikeda Haruo, with the ministry of Health, Labour and Welfare scientific research support)

The diagnosis of gastrointestinal cancer generally requires histopathological assessment of multiple endoscopic biopsies. In cases were biopsies are not possible (such as in patients under antiplatelet therapy) is possible to assess the structure of the mucosal glands and the vessels’ pattern with the use of high resolution and magnification endoscopy (endocytoscopy). The in-vivo assessment of glandular and vascular pattern as a predictor of malignancy has been demonstrated as a reliable and effective prognostic index.

Link to ePUB:

• Inoue H, Sasajima K, Kaga M, et al Endoscopic in vivo Evaluation of Tissue Atypia in the esophagus USING A newly designed integrated Endocytoscope: A pilot trial. Endoscopy.2006; 38: 891-895
  

2015 Review. Submucosal Endoscopy. From ESD to POEM and Beyond

Inoue, Haruhiro, Santi, Esperanza Grace, Onimaru, Manabu, Kudo, Shin Ei

Peroral endoscopic myotomy (POEM) is an evolving minimally invasive endoscopic surgical procedure, with no skin incision, intended for long-term recovery from symptoms of esophageal achalasia. POEM was developed based on both the already established surgical principles of esophageal myotomy and the advanced techniques of endoscopic submucosal dissection. This article relates how POEM was developed, and its use in practice is reported and discussed. As an extension of the POEM technique, submucosal endoscopic tumor resection is introduced.

Link to Epub

Submucosal Endoscopy: From ESD to POEM and Beyond. Haruhiro Inoue, MD, PhD , Esperanza Grace Santi, MD, PhD, Manabu Onimaru, MD, PhD, Shin-ei Kudo, MD, PhD

2015 Review. Peroral endoscopic Myotomy: An evolving Treatment for Achalasia

Robert Bechara, Haruo Ikeda, and Haruhiro Inoue.

Peroral endoscopic myotomy (POEM) was first performed in Japan in 2008 for uncomplicated achalasia. With excellent results, it was adopted by highly skilled endoscopists around the world and the indications for POEM were expanded to include advanced sigmoid achalasia, failed surgical myotomy, patients with previous endoscopic treatments and even other spastic oesophageal motility disorders. With increased uptake and performance of POEM, variations in technique and improved management of adverse events have been developed. Now, 6 years since the first case and with >3,000 procedures performed worldwide, long- term data has shown the efficacy of POEM to be long-lasting. A growing body of literature also exists pertaining to the learning curve, application of novel technologies, extended indications and physiologic changes with POEM. Ultimately, this once experimental procedure is evolving towards becoming the preferred treatment for achalasia and other spastic oesophageal motility disorders.

Link to Epub

• http://www.nature.com/doifinder/10.1038/nrgastro.2015.87

2015 original papers

• Greater curvature Myotomy Is a Safe and Effective modified Technique in per-Oral endoscopic Myotomy. 
  Manabu Onimaru , Haruhiro Inoue, Haruo Ikeda, Chiaki Sato, Hiroki Sato, Chainarong Phalanusitthepha, Esperanza Grace Santi, Kevin L. Grimes, Hiroaki Ito, and Shin- . EI Kudo 
  Gastrointest Endosc 2015 Jun; 81 (6):.. 1370-7 doi: 10.1016 / J.Gie.2014.11.014 (published Online: 14 Feb 2015).

• Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients. 
  Hiroaki Ito , Katsuyuki Hasegawa, Yuuki Hasegawa, Tadashi Nishimaki, Kazuyoshi Hosomichi, Satoshi Kimura, Motoi Ohba, Hiroshi Yao, Manabu Onimaru, Ituro Inoue, and Haruhiro . inoue 
  Nature Publishing Group, Scientific Reports 5:.. 10455 doi: 10.1038 / Srep10455 (published Online: 21 May 2015).

• Novel Methodology for the Detection of Circulating tumor cells in gastric Cancer and Cell-free nucleic Acids in gastrointestinal malignancies. 
  Hiroaki Ito , Katsuyuki Hasegawa, Yuuki Hasegawa, Satoshi Kimura, Manabu Onimaru, Noriko Yamaguchi, Haruo Ikeda, Mitsuo Saito, and Haruhiro Inoue. 

• Change of number and size of Circulating tumor cells with high telomerase activity During Treatment of Patients with gastric Cancer. 
  Hiroaki Ito , Noriko Yamaguchi, Manabu Onimaru, Satoshi Kimura, Tohru Ohmori, fumihiro Ishikawa, Jun Sato, Shun Ito and Haruhiro Inoue. 
  Oncology Letters (in Press).

2014 Original papers

• Anti-reflux Mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia:. A pilot Study
  Haruhiro Inoue , Hiroaki Ito, Haruo Ikeda, Chiaki Sato, Hiroki Sato, Chainarong Phalanusitthepha, Bu'Hussain Hayee, Nikolas Eleftheriadis, and Shin-EI Kudo . 
  Annals of Gastroenterology 2014; 27 (4):. 1-6.
  
• Use of surface-Enhanced Raman scattering for Detection of Cancer-related serum-Constituents in gastrointestinal Cancer Patients.
  Hiroaki Ito , Haruhiro Inoue, Katsuyuki Hasegawa, Yuuki Hasegawa, Takehiko Shimizu, Satoshi Kimura, Manabu Onimaru, Haruo Ikeda, and Shin-EI Kudo . 
  Nanomedicine:. Nanotechnology, Biology and Medicine 2014; 10 (3): 599-608.

• Evaluation of the safety and Efficacy of Esophagojejunostomy after Totally Laparoscopic Total Gastrectomy USING A trans-Orally inserted Anvil:. A single-Center Comparative Study Hiroaki Ito , Haruhiro Inoue, Noriko Odaka, Hitoshi Satodate, Manabu Onimaru, Haruo Ikeda, Daisuke Takayanagi, Kenta . Nakahara, and Shin-EI Kudo Surgical Endoscopy 2014; 28 (6):. 1929-1935.

• Prognostic impact of the number of viable Circulating cells with high telomerase activity in gastric Cancer Patients:. A prospective Study
  Hiroaki Ito ., Haruhiro Inoue, Satoshi Kimura, Tohru Ohmori, fumihiro Ishikawa, Keigo Gohda, and Jun Sato 
  . Internatonal Journal of Oncology 2014 ; 45: 227-234.

• Improved Optical identification of Lateral spreading type "0-IIb" gastric lesion with narrow band Imaging Magnification Endoscopy.
  Nikolas Eleftheriadis , Haruhiro Inoue, Haruo Ikeda, Roberta Maselli, Manabu Onimaru, Akira Yoshida, Hiroaki Ito, Shigeharu Hamatani, and Shin-EI . kudo 
  . Annals of Gastroenterology 2014; 27 (3): 1-3.